GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs13256369 | 1 | rs4841017 | chr8:8577093 | SGK223 | chr8:8175259-8239257:- | -0.31 | -5.62 | 3.25E-8 | Obesity-related traits |
| THCA | cis | rs8030379 | 1 | rs4842838 | chr15:84582124 | LOC388152 | chr15:84867600-84898920:- | 0.21 | 3.96 | 8.74E-5 | Waist circumference adjusted for body mass index;Waist circumference |
| THCA | cis | rs8030379 | 1 | rs4842923 | chr15:84581904 | LOC388152 | chr15:84867600-84898920:- | -0.2 | -3.72 | 0.000226 | Waist circumference adjusted for body mass index;Waist circumference |
| THCA | cis | rs8030379 | 1 | rs4842924 | chr15:84587607 | LOC388152 | chr15:84867600-84898920:- | 0.2 | 3.8 | 0.000164 | Waist circumference adjusted for body mass index;Waist circumference |
| THCA | cis | rs377457 | 1 | rs4843575 | chr16:85735642 | GINS2 | chr16:85711281-85722588:- | -0.21 | -4.21 | 3.07E-5 | Type 2 diabetes |
| THCA | cis | rs6600671 | 1 | rs4844380 | chr1:121193620 | HIST2H2BA | chr1:120906034-120914842:+ | 0.21 | 4.87 | 1.55E-6 | Hip geometry |
| THCA | cis | rs6600671 | 1 | rs4844381 | chr1:121184898 | HIST2H2BA | chr1:120906034-120914842:+ | 0.22 | 4.98 | 9.02E-7 | Hip geometry |
| THCA | cis | rs12134133 | 1 | rs4844588 | chr1:207429668 | CD55 | chr1:207494817-207534309:+ | 0.19 | 7.47 | 3.96E-13 | Posterior cortical atrophy and Alzheimer's disease |
| THCA | cis | rs12134133 | 1 | rs4844590 | chr1:207496129 | CD55 | chr1:207494817-207534309:+ | 0.19 | 7.44 | 4.83E-13 | Posterior cortical atrophy and Alzheimer's disease |
| THCA | cis | rs12134133 | 1 | rs4844590 | chr1:207496129 | CR1 | chr1:207669473-207815109:+ | -0.13 | -3.41 | 0.000701 | Posterior cortical atrophy and Alzheimer's disease |
| THCA | cis | rs891378 | 1 | rs4844591 | chr1:207500293 | CD55 | chr1:207494817-207534309:+ | 0.15 | 6.69 | 6.37E-11 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs891378 | 1 | rs4844592 | chr1:207501211 | CD55 | chr1:207494817-207534309:+ | 0.15 | 6.6 | 1.12E-10 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs6600671 | 1 | rs4844607 | chr1:121184059 | HIST2H2BA | chr1:120906034-120914842:+ | -0.19 | -4.5 | 8.72E-6 | Hip geometry |
| THCA | cis | rs6600671 | 1 | rs4844616 | chr1:121171208 | HIST2H2BA | chr1:120906034-120914842:+ | 0.23 | 5.14 | 4.09E-7 | Hip geometry |
| THCA | cis | rs3126085 | 1 | rs4845756 | chr1:152254919 | FLG | chr1:152274651-152297679:- | -0.3 | -4.71 | 3.27E-6 | Atopic dermatitis |